CLAMOX 625 

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Co-Amoxiclav

Tab.125/500 mg

Clamox^® (Amoxicillin /Clavulanate potassium)

Description

Clamox^® is an oral antibacterial combination consisting of semisynthetic antibiotic amoxicillin and the β-lactamase inhibitor, clavulanate potassium.

Clinical pharmacology

The formulation of amoxicillin and clavulanic acid in Clamox^® protects amoxicillin from degradation by β-lactamase enzymes and effectively extends the antibiotic spectrum of amoxicillin to include many bactria normally resistant to amoxicillin and other β-lactam antibiotics. Thus Clamox^® possesses the distinctive properties of a broad-spectrum antibiotic and a β -lactamase inhibitor.

Antibacterial activity

Gram-Positive Aerobes:

Staphylococcus aureus(beta-lactamase and non –beta- lactamase-producing ), Staphylococci which are resistant to methicillin/oxacillin should be considered as resistant to Clamox^®.

Gram-Negative Aerobes:

Enterobacter species (Although most strains of Enterobacter species are resistant in vitro, clinical efficacy has been demonstrated with Clamox^® are resistant in vitro, clinical efficacy has been demonstrated with Clamox^® in urinary tract infections caused by these organisms.) Escherichia coli (beta-lactamase- and non –beta- lactanase-producing), Haemophilus influenzae (beta-lactamase- and non –beta- lactamase-producing,) Klebsiella species (all known strains are beta- lactamase producing), -Moraxella catarrehalis ((beta)-lactamase- and non –beta- lactamase-producing.

Pharmacokinetics

Oral absorption well absorbed

Presystemic metabolism ----

Plasma half – life range 1.3 h

Volume of distribution 0.36 L.kg^-1

Plasma protein binding

Amoxicillin ~ 18%

Clavulanic acid ~ 25%

Indication

1- Lower respiratory tract infections

2- Urinary tract infection

3- Skin and skin structure infections

4- Sinusitis

5- Otitis media

Contraindication

Clamox^® is contraindicated for patients known to have hypersensitivity to any of the penicillins and in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with Clamox^®