AMPIRAL 250 mg 

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Ampicillin

Cap. 250 mg

Ampiral^® (Ampicillin)

Description

Ampiral^® is a semisynthetic antibiotic, with a broad spectrum of bactericidal activity.

Clinical pharmacology

Ampiral^® is similar to Amoxicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide. Ampiral^® has been shown to be active against most strains of the following microorganisms.

Antibacterial activity

Aerobic Gram-Positive Microorganisms:

Enterococcus faecalis Staphylococcus spp. * ((beta)-lactamase-negative strains only) ,Streptococci,Streptococcus pneumoniae Streptococcus spp. ((alpha) - and (beta)-hemolytic strains only) *, Bacillus anthracis, Listeria monocytogenes

Aerobic Gram-Negative Microorganisms:

Escherichia coli ((beta)-lactamase-negative strains only) Haemophilus influenzae ((beta)-lactamase-negative strains only) Neisseria gonorrhoeae, Neisseria meningitides, Salmonella sp. Shigella sp., Proteus mirabilis

Anaerobic

Clostridium sp., peptococcus sp.

Pharmacokinetics

Oral absorption rapidly

Presystemic metabolism ----

Plasma half – life range 61.3 min

Volume of distribution 0.291.kg^-1

Plasma protein binding ~ 20%

Indication

1- Genitourinary tract infections

2- Respiratory tract infections

3- GI tract infections

4- Meningitis