AMPIVIL 250mg 

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Ampicillin

Vial.250 mg

Ampivil^® (Ampicillin)

Description

Ampivil^® is a beta-lactam antibiotic, with a broad spectrum of bactericidal activity.

Clinical pharmacology

Ampivil ^® is similar to amoxicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide. Ampicillin has been shown to be active against most strains of the following microorganisms.

Antibacterial activity

Aerobic Gram-Positive Microorganisms:

Enterococcus faecalis, Streptococcus pneumonia, Listeria monocytogenes,

Aerobic Gram-Negative Microorganisms:

Moraxella catarrhalies(branhamella catarrhalis), Escherichia coli, Haemophilus influenzae ,Neisseria gonorrhoeae ,Proteus mirabilis ,Salmonella and Shigella spp.

Pharmacokinetics

Oral absorption -----

Presystemic metabolism -----

Plasma half – life range 1 -1.5 h

Volume of distribution 0.17-0.31 L.kg^-1

Plasma protein binding ~ 20%

Indication

1- Respiratory tract infections

2- Bacterial meningitis

3- Septicemia and endocarditis

4- Urinary tract infections

5- GI infections

6- Genitourinary tract infections:

Contraindication

Ampivil^® is contraindicated for patients known to have hypersensitivity to any of the penicillins.

Precaution

· Ampivil^® should be stopped if a skin rash occurs

· It should preferably not be given to patients with infectious mononucleosis

· Care is necessary if very high doses of Ampivil^® are given, especially if renal function is poor, because of the risk of neurotoxicity.

· High doses of Ampivil^® should also be used with caution in patients receiving potassium-containing drugs or potassium-sparing diuretics

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